Dalteparin and Radiation Therapy in Treating Patients With Newly Diagnosed Supratentorial Glioblastoma Multiforme

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically or cytologically confirmed newly diagnosed supratentorial glioblastoma multiforme
• At least 2 weeks but no more than 4 weeks since prior surgery
• * Patients with biopsy only must be at least 1 week past surgery
• PATIENT CHARACTERISTICS:
• Age:
• 18 and over
• Performance status:
• ECOG 0-2
• Life expectancy:
• Not specified
• Hematopoietic:
• Platelet count at least 100,000/mm\^3
• No history of heparin-induced thrombocytopenia
• No coagulopathy
• Hepatic:
• Bilirubin no greater than 2.5 mg/dL
• AST no greater than 3 times upper limit of normal (ULN)
• PT/aPTT no greater than 1.5 times ULN
• Renal:
• Creatinine no greater than 2.0 mg/dL
• No gross hematuria within the past 6 months
• Cardiovascular:
• No uncontrolled hypertension
• No unstable angina
• No symptomatic congestive heart failure
• No myocardial infarction within the past 6 months
• No uncontrolled cardiac arrhythmia
• Gastrointestinal:
• No peptic ulcer disease within the past 6 months
• Negative stool guaiac
• * Negative endoscopy required if positive stool guaiac
• Other:
• No known hypersensitivity to dalteparin, heparin, or pork products
• No CNS trauma within the past 3 months
• No intracranial or intraocular hemorrhage, unless related to surgery, within the past 6 months
• No retinal detachment within the past 6 months
• No other concurrent malignancy receiving treatment
• No active infection
• No AIDS-related illness
• HIV negative
• Must weigh at least 90 pounds (40 kg)
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• PRIOR CONCURRENT THERAPY:
• Biologic therapy:
• No concurrent immunomodulators
• No concurrent investigational matrix metalloproteinase inhibitors or antiangiogenesis agents
• Chemotherapy:
• Prior chemotherapy for other malignancy allowed
• No concurrent standard or investigational cytotoxic chemotherapy
• Endocrine therapy:
• Not specified
• Radiotherapy:
• No prior cranial irradiation
• Prior radiotherapy for other malignancy allowed
• Concurrent radiotherapy allowed
• Surgery:
• See Disease Characteristics
• Recovered from prior surgery
• No prior eye or ear surgery
• Other:
• No concurrent nonsteroidal anti-inflammatory drugs
• No ongoing or concurrent aspirin or anticoagulation therapy except routine central venous catheter flushing
• No other concurrent non-protocol therapy