Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Memorial Sloan Kettering Cancer Center
With
National Cancer Institute (NCI)
OBJECTIVES:
* Determine whether portal vein embolization results in significant hypertrophy of the remaining liver and potentially decreases the risk of liver failure after hepatic resection in patients with liver metastases from primary colorectal cancer.
* Determine the biologic effects of this therapy on liver metastases and normal liver parenchyma in these patients.
OUTLINE: Patients undergo portal vein embolization with 200-300 micron polyvinyl chloride particles suspended in Iohexol 300. Approximately 3-6 weeks after embolization, patients undergo an exploratory laparotomy followed by hepatic surgical resection.
Patients are followed for at least 6 months.
PROJECTED ACCRUAL: A total of 25 patients will be accrued for this study.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
DISEASE CHARACTERISTICS:
Histologically confirmed primary colorectal adenocarcinoma with metastases to the liver being considered for hepatic resection
Requirement for removal of at least 60% of functional liver parenchyma based on CT scan
No extrahepatic disease by laparoscopy
PATIENT CHARACTERISTICS:
Age:
Over 18
Performance status:
ECOG 0-2
Life expectancy:
Not specified
Hematopoietic:
WBC at least 2,000/mm3
Platelet count at least 100,000/mm3
Hepatic:
Bilirubin no greater than 1.8 mg/dL
AST and ALT no greater than 80 IU/L
Renal:
Creatinine no greater than 1.8 mg/dL
Cardiovascular:
No New York Heart Association class III or IV heart disease
Other:
Not pregnant or nursing
Negative pregnancy test
Fertile patients must use effective contraception
PRIOR CONCURRENT THERAPY:
Biologic therapy:
Not specified
Chemotherapy:
At least 1 month since prior systemic chemotherapy
Endocrine therapy:
Not specified
Radiotherapy:
Not specified
Surgery:
See Disease Characteristics
Other:
At least 2 months since prior investigational treatment
Clareo Health | Portal Vein Embolization in Treating Patients With Liver Metastases From Primary Colorectal Cancer
