Safety and Acceptability of the Anti-Microbe Vaginal Gel, PMPA Gel

Inclusion Criteria

• •All female participants may be eligible for this study if they:
• •Are between 18 and 45 years of age.
• •Have a menstrual cycle with at least 21 days between periods or have not menstruated for at least 6 months.
• •Agree from the time of Screening Visit until the Day 14 Follow-up Visit to: a) not use IV drugs (except for therapeutic use) and b) not participate in other microbicide or contraceptive studies.
• •Agree not to take part in the following activities for at least 48 hours before the study enrollment visit (Day 0) until the Day 14 Follow-up Visit: anal intercourse; douching; oral contact with the vagina; penetration of the vagina by fingers, sex toys, or any other objects; use of any vaginal product, including lubricants, drying agents, feminine hygiene products, diaphragms, and cervical caps.
• •Agree to insert the PMPA gel in the exact way it is specified.
• •Abstinent Women (Groups A1-A4, C, and V) may be eligible for this study if they:
• •Agree to abstain from vaginal intercourse from 48 hours before study until Day 14.
• •HIV-infected abstinent women (C) must be HIV infected; have a CD4 count of at least 200/mm3 at time of screening and within 6 months prior to screening, and a viral load of 10,000 copies/ml or less if on anti-HIV therapy or have a viral load of less than 55,000 if not on anti-HIV therapy; provide study staff access to HIV medical records and be under medical care for HIV management; and be on stable anti-HIV therapy (if any) for 1 month before screening and expect to stay on that therapy throughout the study.
• •Sexually Active Women (Groups B and D) may be eligible for this study if they:
• •Agree to abstain from vaginal intercourse for 48 hours before study start.
• •Agree to tell their mutually monogamous male sexual partner about their participation in the trial and of requirements from Day 0 until Day 14 to have vaginal intercourse at least twice weekly and to use a study-provided male latex condom for every sexual episode.
• •HIV-uninfected sexually active women (B) must currently have a single male HIV-uninfected sexual partner who is at low risk for HIV infection and who can be included in the study.
• •HIV-infected sexually active women (D) must have a CD4 count of at least 200/mm3 at time of screening and within 6 months prior to screening, and a viral load of 10,000 copies/ml or less if on anti-HIV therapy or have a viral load of less than 55,000 if not on anti-HIV therapy; provide study staff access to HIV medical records and be under medical care for HIV management; be on stable anti-HIV therapy (if any) for 1 month before screening and expect to stay on that therapy throughout the study; and currently have a single male HIV-infected sexual partner who can be included in the study.
• •Male sexual partners of sexually active participants (Groups B and D) must be:
• •At least 18 years old and in a relationship with the study participant for at least 3 months and be willing to maintain this relationship for the entire study.
• •At low risk for HIV infection and be HIV-uninfected if female partner is HIV-uninfected (B) or be HIV-infected if female partner is HIV-infected (D).
• •Able and willing to have vaginal intercourse with only the study participant at least 2 times per week, and to use study-provided lubricated male condoms each time during study.
• •Willing to not have vaginal intercourse for 48 hours before Day 0.
• •Willing to abstain from the following from 48 hours before Day 0 until the end of study product use: anal intercourse, oral contact with the vagina, and penetration of the vagina by fingers, sex toys, or any other objects.
• •Willing to take part in an interview after the study and undergo clinical evaluations.
• •(This study has been changed to expand the CD4 cell count criterion for Groups C and D.)