Androgen Replacement Therapy in Women With Hypopituitarism

Exclusion Criteria

• •Any disease known to affect bone metabolism, including untreated hypothyroidism or hyperthyroidism
• •Change in thyroid hormone dose in the last 3 months
• •Untreated Cushing's syndrome
• •Renal failure
• •Alcoholism
• •Anorexia nervosa
• •Prior use of medication known to affect bone metabolism (e.g., supraphysiologic doses of glucocorticoids, phenytoin, bisphosphonates, or calcitonin) within the past 3 months
• •Pregnant or nursing
• •Uncontrolled hypertension
• •ALT greater than 3 times upper limit of normal
• •Serum creatinine greater than 2 times the upper limit of normal
• •Any contraindication to estrogen therapy, including history of breast cancer or undiagnosed uterine bleeding
• •Concurrent growth hormone replacement therapy, if patient has been receiving it for less than 2 years