Collection of Blood and Urine From Patients Undergoing Radiation Therapy

BACKGROUND: Evolving research initiatives in the Radiation Oncology Branch (ROB) NCI, depend upon the availability of blood and urine samples from patients receiving radiotherapy. Examples of planned studies include an exploration of the effects of radiotherapy on peripheral leukocyte phenotype, peripheral blood protein and metabolism changes as well as measurements of matrix metalloproteinases (MMP) in urine. OBJECTIVES: This protocol provides a means of acquiring blood and urine samples in patients receiving radiation therapy for a variety of conditions. ELIGIBILITY: Patients seen in the radiation oncology clinic will be asked to donate blood and/or urine before, during and after their treatment. DESIGN: This is a pilot, exploratory study to evaluate the effects of ionizing radiation in blood and/ or urine. On most occasions, the blood samples will be obtained as a component of routine patient monitoring and will not necessitate an additional venipuncture. Blood and urine samples will be processed and stored in the Radiation Oncology Branch and Basic Research Laboratory, CCR, NCI, for use in the research efforts of the branch.