A Study of Dryvax Vaccine Against Smallpox in Previously Unvaccinated Adults

Exclusion Criteria

• •Patients may not be eligible for this study if they:
• •Have a suppressed immune system.
• •Have participated in an HIV vaccine trial.
• •Have liver disease, diabetes, or kidney problems.
• •Have malignant skin cancer.
• •Have autoimmune disease.
• •Have used medication that suppresses the immune system.
• •Have had psychiatric or medical problems or have job responsibilites that will keep them from participating in the study.
• •Use illegal intravenous drugs.
• •Have received any live vaccines within 60 days of study start.
• •Have used experimental therapies within 30 days before study start.
• •Have been vaccinated with certain experimental vaccines.
• •Have a vaccination scar but have no record of having a vaccine.
• •Have received a smallpox vaccine.
• •Have taken blood products or immunoglobulin in the past 6 months.
• •Have a fever on the day of vaccination.
• •Have certain skin disorders, including eczema, exfoliative skin, lacerations that require stitches or burns larger than 2 x 2 cm.
• •Live with, have sexual contact with, or work with anyone who is pregnant, less than a year old, has eczema, has certain skin disorders, has a disease or takes medication that suppresses the immune system.
• •Have a condition that, in the opinion of the investigator, might interfere with the study.
• •Are allergic to any parts of the vaccine.
• •Are allergic to thimerosal, immunoglobulins, cidofovir, or probenecid.
• •Are pregnant or breast feeding.