Brain Activation in Vocal and Motor Tics

Inclusion Criteria

• •Patients will have a clinically documented tic disorder as defined by DSM-IV-TR and evaluation of tics severity using Yale Tic Sale. This criterion will be established by the preliminary screening in the NINDS Movement Disorders Outpatient Clinic.
• •Patients will be in age range 14 to 65.
• •Patients may be male or female.
• •Patients will be asked to stop any medications that can influence central nervous system for at least 24 hours prior to exam also they will be asked to abstain from alcohol for 24 hours before the study.
• •10 normal controls will be included; controls will be screened in the NINDS Movement Disorders Outpatient Clinic, and will have neurological and physical examination.
• •Controls with chronic illnesses, taking any medication that affects the CNS will be excluded.
• •Controls will be asked to abstain from alcohol for 24 hours before the study.
• •All subjects participating in MR studies should have a valid Clinical Center Medical Record Number.