Finding studies
Finding studies
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Lead
SWOG Cancer Research Network
With
OBJECTIVES: * Determine the feasibility of treating elderly women with metastatic breast cancer with docetaxel. * Determine the overall survival, 2-year survival, and response (confirmed and unconfirmed complete and partial) in patients treated with this drug. * Determine the toxicity and tolerability of this drug in these patients. * Determine the feasibility of using standardized self-report measures of comorbidity, depression, and functional status in elderly cancer patients. * Determine the parameters of clinical pharmacology of this drug in elderly patients and in patients under 60 years of age. * Determine, preliminarily, the genetic polymorphisms and gene expression levels of enzymes involved in drug metabolism and resistance in patients treated with this drug. OUTLINE: Patients are stratified according to age (70 and over vs under 60). Patients receive docetaxel IV over 1 hour on day 1. Treatment repeats every 21 days in the absence of disease progression or unacceptable toxicity. Patients are followed every 3 months for 3 years. PROJECTED ACCRUAL: Approximately 80 patients (60 patients age 70 and over and 20 patients under age 60) will be accrued for this study.
Age
18–any
Sex
FEMALE
Healthy volunteers
Not accepted