R115777 in Treating Patients With Advanced Solid Tumors

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Histologically confirmed malignant tumors deemed to be incurable or refractory to therapy
• •* Advanced, recurrent, or metastatic disease
• •Previously treated with at least 1 chemotherapy regimen
• •Brain metastases allowed if asymptomatic and controlled (e.g., after prior surgical resection or radiotherapy/radiosurgery) and not on steroids or anticonvulsants
• •PATIENT CHARACTERISTICS:
• •Age:
• •18 and over
• •Performance status:
• •Karnofsky 60-100%
• •Life expectancy:
• •Not specified
• •Hematopoietic:
• •WBC at least 3,500/mm3
• •Absolute granulocyte count at least 1,500/mm3
• •Platelet count at least 75,000/mm3
• •Hepatic:
• •Bilirubin no greater than 2.5 times upper limit of normal (ULN)
• •SGOT no greater than 2.5 times ULN
• •Renal:
• •Creatinine clearance at least 60 mL/min OR
• •Creatinine no greater than 1.6 mg/dL
• •Other:
• •Not pregnant or nursing
• •Negative pregnancy test
• •Fertile patients must use effective contraception during and for 3 months after study
• •PRIOR CONCURRENT THERAPY:
• •Biologic therapy:
• •No concurrent biologic therapy
• •Chemotherapy:
• •See Disease Characteristics
• •At least 4 weeks since prior chemotherapy (6 weeks for mitomycin or nitrosourea)
• •Endocrine therapy:
• •See Disease Characteristics
• •No concurrent hormonal therapy
• •Radiotherapy:
• •See Disease Characteristics
• •At least 4 weeks since prior radiotherapy and recovered
• •No prior radiotherapy to a field containing a measurable target lesion unless there is evidence of progression or a new lesion is present
• •No concurrent radiotherapy to measurable lesions
• •Surgery:
• •See Disease Characteristics
• •At least 3 weeks since prior major surgery and recovered
• •Other:
• •At least 2 weeks since prior proton pump inhibitors (e.g., omeprazole)
• •Concurrent H2 blockers (e.g., cimetidine or related drugs) or antacids are allowed if there is an interval of at least 2 hours between H2 blocker/antacid intake and R115777 dosing