Carboplatin and Irinotecan in Treating Children With Refractory Solid Tumors

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically or cytologically confirmed solid tumor, including primary brain tumor
• * Progressive disease on standard therapy or for which no standard therapy exists
• No symptomatic brain metastases
• PATIENT CHARACTERISTICS:
• Age:
• 1 to 21
• Performance status:
• Lansky 50-100% (age 10 and under)
• Karnofsky 50-100% (over age 10)
• Life expectancy:
• At least 8 weeks
• Hematopoietic:
• Absolute neutrophil count greater than 1,000/mm3
• Platelet count greater than 100,000/mm3
• Hepatic:
• Bilirubin no greater than 1.5 mg/dL
• ALT no greater than 2.5 times upper limit of normal
• Renal:
• Glomerular filtration rate at least 30 mL/min
• Other:
• No active infection
• No serious uncontrolled medical disorder
• No psychiatric disorder or other disorder that would preclude study
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• PRIOR CONCURRENT THERAPY:
• Biologic therapy:
• At least 6 months since prior allogeneic bone marrow transplantation without evidence of acute or chronic graft versus host disease
• At least 3 months since prior autologous bone marrow or peripheral blood stem cell transplantation
• At least 4 weeks since prior immunotherapy and recovered
• No concurrent immunotherapy
• Chemotherapy:
• No more than 3 prior chemotherapy regimens
• At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin) and recovered
• No other concurrent chemotherapy
• Endocrine therapy:
• Concurrent hormone replacement therapy or oral contraceptives allowed
• No other concurrent hormonal therapy
• Radiotherapy:
• At least 4 weeks since prior radiotherapy (including for brain metastases) and recovered
• No concurrent radiotherapy
• Surgery:
• Not specified
• Other:
• No other concurrent investigational anticancer drugs
• No other concurrent antitumor therapy
• No concurrent anticonvulsants (e.g., phenytoin, phenobarbital, or carbamazepine) except gabapentin (Neurontin)