Monoclonal Antibody Therapy in Treating Patients With Prostate Cancer

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically confirmed prostate cancer
• Disease progression after prior castration
• * At least 3 rising PSA levels at least 1 week apart OR 2 rising levels at least 4 weeks apart
• New osseous lesions on bone scan and/or more than 25% increase in bidimensionally measurable soft tissue disease or appearance of new sites of disease by CT scan or MRI
• Testosterone no greater than 50 ng/mL
• * Medical therapy (e.g., gonadotropin-releasing hormone analogues) to maintain castrate level of testosterone should continue in the absence of surgical orchiectomy
• Progression of disease after discontinuation of prior anti-androgen therapy
• No requirement for palliative therapy within the past 12 weeks
• No active CNS or epidural primary tumor OR active CNS or epidural metastases
• PATIENT CHARACTERISTICS:
• Age:
• 18 and over
• Performance status:
• Karnofsky 60-100%
• Life expectancy:
• Not specified
• Hematopoietic:
• WBC greater than 3,500/mm3
• Platelet count greater than 100,000/mm3
• Hepatic:
• Bilirubin less than 1.5 mg/dL
• Gamma-glutamyl-transferase less than upper limit of normal (ULN)
• AST less than ULN
• PT less than 14 seconds
• No prior autoimmune hepatitis
• Renal:
• Creatinine less than 1.5 mg/dL OR
• Creatinine clearance greater than 60 mL/min
• Cardiovascular:
• No clinically significant cardiac disease (New York Heart Association class III or IV)
• Pulmonary:
• No severe debilitating pulmonary disease
• Other:
• Fertile patients must use effective contraception
• No active uncontrolled infection or infection requiring IV antibiotics
• No prior autoimmune disease
• PRIOR CONCURRENT THERAPY:
• Biologic therapy:
• No prior murine protein for diagnostic or therapeutic purposes
• No other concurrent anticancer immunotherapy
• Chemotherapy:
• At least 4 weeks since prior chemotherapy and recovered
• No concurrent anticancer chemotherapy
• Endocrine therapy:
• See Disease Characteristics
• No concurrent anticancer hormonal therapy
• Radiotherapy:
• At least 4 weeks since prior radiotherapy and recovered
• Concurrent radiotherapy to localized sites of disease (e.g., bone) allowed if the site does not contain sole measurable lesion
• Surgery:
• See Disease Characteristics
• No concurrent surgery
• Other:
• Recovered from all prior therapy
• At least 4 weeks since prior therapeutic investigational anticancer drugs
• At least 4 weeks since prior participation in therapeutic clinical trial with an experimental drug
• No prior diagnostic ProstaScint, Myoscint, or Oncoscint scans
• No other concurrent therapeutic investigational anticancer agents
• No concurrent participation in other therapeutic clinical trial with an experimental drug