SU6668 in Treating Patients With Advanced Solid Tumors

Inclusion Criteria

• •Histologically confirmed advanced solid tumor for which no standard therapy exists
• •At least 1 measurable tumor lesion (at least 2 cm) not previously irradiated
• •No history of brain metastases
• •* Negative brain CT/MRI required for patients with signs and symptoms suspicious for brain metastases
• •Performance status - ECOG 0-1
• •WBC greater than 3,000/mm\^3
• •Absolute neutrophil count greater than 1,500/mm\^3
• •Platelet count greater than 100,000/mm\^3
• •Hemoglobin greater than 10 g/dL
• •No history of bleeding diathesis
• •Bilirubin no greater than 1.5 times upper limit of normal (ULN)
• •ALT less than 2.5 times ULN
• •Creatinine less than 1.5 mg/dL
• •Creatinine clearance greater than 60 mL/min
• •No concurrent uncontrolled medical or psychiatric disorders
• •No severe iodine allergy
• •Not pregnant or nursing
• •Negative pregnancy test
• •Fertile patients must use effective contraception
• •At least 30 days since prior over-the-counter, anticancer biologic agents (e.g., shark cartilage)
• •No concurrent over-the-counter, anticancer biologic agents (e.g., shark cartilage)
• •At least 3 weeks since prior cytotoxic or cytostatic agents (6 weeks for nitrosoureas or mitomycin)
• •Patients with ECOG performance status 0:
• •* Any number of prior chemotherapy regimens allowed
• •Patients with ECOG performance status 1:
• •* No more than 3 prior chemotherapy regimens for metastatic or recurrent disease
• •* The same drug given on a different schedule does not count as a different regimen
• •* Prior adjuvant chemotherapy for non-metastatic disease or as part of a concurrent chemoradiotherapy protocol is allowed but does not count as part of the 3-regimen limit
• •See Disease Characteristics
• •See Chemotherapy
• •At least 3 weeks since prior radiotherapy to nonindicator lesions
• •No concurrent radiotherapy
• •At least 24 hours since prior minor surgery (e.g., central venous catheter placement)
• •At least 4 weeks since prior major surgery (e.g., laparotomy, thoracotomy, or craniotomy)
• •At least 30 days since prior anticancer herbal remedies
• •At least 30 days since prior investigational agents
• •No concurrent anticancer herbal remedies
• •No other concurrent investigational or anticancer medication