Finding studies
Finding studies
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Lead
AIDS Malignancy Consortium
With
OBJECTIVES: * Determine the response rate of patients with AIDS-related lymphoma treated with allogeneic peripheral blood stem cell (PBSC) transplantation followed by delayed donor leukocyte infusion. * Determine the complication rate of these patients treated with PBSC transplantation. * Determine the immune dysfunction and recovery of patients treated with this regimen. OUTLINE: This is a multicenter study. Patients receive cyclophosphamide IV over 60 minutes on days -5 to -3. Patients who have not received prior mediastinal radiotherapy receive thymic radiotherapy on day -1. Allogeneic peripheral blood stem cells are infused on day 0. Patients also receive anti-thymocyte globulin IV over 10-12 hours on days -1, 1, 3, and 5 and cyclosporine IV beginning on day -1, switching to oral when possible, and tapering until day 35. In the absence of active acute graft-versus-host disease (GVHD), and at least 2 weeks after completion of cyclosporine, patients receive an infusion of donor leukocytes on or before day 49. Patients may receive a second donor leukocyte infusion if there is evidence of persistent malignancy and no GVHD. Patients are followed through day 100, on days 120, 180, 270, and 365, and then every 6 months thereafter. PROJECTED ACCRUAL: A total of 12-35 patients will be accrued for this study within 3-4 years.
Age
0–65
Sex
ALL
Healthy volunteers
Not accepted