Radiation Therapy With or Without SU5416 in Treating Patients With Soft Tissue Sarcoma

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Histologically confirmed primary or locally recurrent stage IB or IIA soft tissue sarcoma
• •* Grade 1 or 2
• •* Tumor greater than 5 cm in diameter
• •Tumor located on upper extremities (including shoulder), lower extremities (including hip), or body wall
• •No sarcoma of the head and neck or intra-abdominal or retroperitoneal sarcoma
• •No desmoid tumor or dermatofibrosarcoma protuberans
• •No metastatic disease
• •No evidence of lung metastases
• •* Maximum of 4 lung lesions no greater than 5 mm in diameter each on preoperative chest CT scan allowed OR
• •* Lesion no greater than 1 cm allowed if stable for at least 1 year and fits criteria for granuloma
• •PATIENT CHARACTERISTICS:
• •Age:
• •18 and over
• •Performance status:
• •Zubrod 0-1
• •Life expectancy:
• •At least 2 years
• •Hematopoietic:
• •WBC at least 4,000/mm\^3 OR
• •Absolute neutrophil count at least 1,800/mm\^3
• •Platelet count at least 100,000/mm\^3
• •Hepatic:
• •Bilirubin no greater than 1.5 mg/dL
• •SGOT no greater than 50 U/L
• •PT and PTT less than 1.25 times normal (not on warfarin)
• •Renal:
• •Creatinine no greater than 1.5 mg/dL OR
• •Creatinine clearance greater than 50 mL/min
• •Cardiovascular:
• •No congestive heart failure or myocardial infarction within the past 6 months
• •No uncompensated coronary artery disease
• •No severe peripheral vascular disease
• •No peripheral vascular disease with diabetes mellitus
• •No deep venous or arterial thrombosis within the past 3 months
• •Fibrin split products less than 2 times normal
• •Fibrinogen greater than 200 mg/dL
• •Pulmonary:
• •No pulmonary embolism within the past 3 months
• •Other:
• •Not pregnant or nursing
• •Negative pregnancy test
• •Fertile patients must use effective contraception
• •No contraindications to surgery
• •No active uncontrolled bacterial, viral, or fungal infection
• •No other prior or concurrent malignancy within the past 5 years except surgically treated carcinoma in situ of the cervix or squamous cell or basal cell skin cancer
• •No other serious medical or psychiatric illness that would preclude informed consent
• •PRIOR CONCURRENT THERAPY:
• •Biologic therapy:
• •No prior biologic therapy for soft tissue sarcoma
• •Chemotherapy:
• •No prior chemotherapy for soft tissue sarcoma
• •Endocrine therapy:
• •Not specified
• •Radiotherapy:
• •No prior radiotherapy for soft tissue sarcoma
• •Surgery:
• •At least 2 weeks since prior minor surgery (e.g., port placement)
• •At least 4 weeks since prior major surgery