Finding studies
Finding studies
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Lead
Kazia Therapeutics Limited
OBJECTIVES: * Determine the maximum tolerated dose of phenoxodiol in patients with refractory solid tumors. * Determine the steady-state pharmacokinetics of this drug in these patients. * Determine the tumor response in patients treated with this drug. OUTLINE: This is a multicenter, dose-escalation study. Patients receive phenoxodiol IV continuously over days 1-7. Treatment repeats every 14 days in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients receive escalating doses of phenoxodiol until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. Patients are followed at 4 weeks. PROJECTED ACCRUAL: Approximately 18-36 patients will be accrued for this study.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
