Developmental Effects On Children Of Women Who Take Antiepileptic Drugs During Pregnancy

Inclusion Criteria

• •Subject must be diagnosed with partial seizures and/or secondary generalization or primary generalized seizures (absence, atonic, myoclonic, and generalized tonic-clonic seizures)
• •Subjects must be on either carbamazepine, lamotrigine, phenytoin, or valproate monotherapy.
• •Mothers must not have a history of drug abuse (including alcohol) in the last year and have no sequelae of drug abuse.
• •Mothers must be able to maintain an accurate seizure diary of major motor seizures
• •Subjects must have an IQ greater than or equal to 70 points.
• •Subjects must have a history of a negative RPR and HIV.
• •Subjects must not have progressive cerebral disease or presence of other major medical illness
• •Subjects must not have exposure to known teratogens during pregnancy, except AEDs.
• •Subjects must not have poor compliance with prenatal care.
• •Subjects must have adequate reading skills to perform the cognitive tests.