Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Age
18–50
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Candidates must be between the ages of 18 and 50.
Candidates must have had insulin-dependent diabetes mellitus (IDDM) for at least 5 years and been under physician care for at least 6 months prior to enrollment in trial.
Eligible candidates will have poorly controlled IDDM and manifest signs and symptoms severe enough to be incapacitating. These symptoms can include episodes of hypoglycemic unawareness (failure to recognize blood glucose levels \< 54 mg/dl) or episodes requiring the assistance of others.
Candidates may have poor diabetes control despite intensive insulin therapy (HbA1c \> 8.0%).
Creatinine clearance should be \> 60 ml/min)
Body Mass Index should be less than 26
Women of child-bearing age must have a negative pregnancy test and agree to follow effective contraceptive measures for the duration of the trial.
You may not be if
Previous or concurrent organ transplant
Previous or concurrent malignancy
Untreated proliferative diabetic retinopathy
Unstable cardiovascular status, including positive stress echocardiography (if \> age 35)
Active infections, including x-ray evidence of pulmonary infection
Peptic ulcer disease, gall stones, or portal hypertension
Abnormal liver function tests
Presence of panel reactive antibodies \> 20%
Creatinine clearance \< 60 ml/min
HbA1c \> 12%
Serological evidence of HIV, HbsAg, or HCV
Anemia (hemoglobin \< 12.0)
Any condition or circumstance, including psychogenic factors, that preclude therapeutic compliance or otherwise make it unsafe to undergo an islet cell transplant.
PSA \> 4 in males
Clareo Health | Islet Cell Transplantation Alone and CD34+ Enriched Bone Marrow Cell Infusion in Patients With Diabetes Mellitus: Steroid-Free Regimen
