Flavopiridol in Treating Patients With Unresectable or Metastatic Kidney Cancer

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically or cytologically confirmed unresectable primary (M0) or metastatic renal cell cancer
• At least 1 unidimensionally measurable lesion
• * At least 20 mm by conventional techniques OR
• * At least 10 mm by spiral CT scan
• * Soft tissue disease that has been previously irradiated within the past 2 months is not considered measurable
• * Soft tissue disease within a previously irradiated field is considered measurable provided disease has progressed and other measurable disease exists outside of the radiation field
• No prior or concurrent brain metastases
• PATIENT CHARACTERISTICS:
• Age:
• Not specified
• Performance status:
• Zubrod 0-2
• Life expectancy:
• Not specified
• Hematopoietic:
• No hypercoagulable state other than renal cell cancer
• Hepatic:
• Not specified
• Renal:
• Not specified
• Cardiovascular:
• No symptomatic congestive heart failure
• No unstable angina pectoris
• No cardiac arrhythmia
• No prior isolated occurrence of deep venous thrombosis within the past 6 months
• Pulmonary:
• No prior isolated occurrence of pulmonary embolism within the past 6 months
• Other:
• No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer, carcinoma in situ of the cervix, or stage I or II cancer in complete remission
• No history of allergic reactions to compounds of similar chemical or biologic composition to flavopiridol (e.g., staurosporine, deschloroflavopiridol, or butyrolactone I)
• No other uncontrolled illness (e.g., diabetes mellitus)
• No ongoing or active infection
• No psychiatric illness or social situation that would preclude study compliance
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• PRIOR CONCURRENT THERAPY:
• Biologic therapy:
• 1 prior immunotherapy regimen comprising interferon and/or interleukin-2 allowed
• At least 28 days since prior immunotherapy and recovered
• No concurrent prophylactic filgrastim (G-CSF)
• Chemotherapy:
• No prior chemotherapy for renal cell cancer
• Endocrine therapy:
• Not specified
• Radiotherapy:
• See Disease Characteristics
• At least 21 days since prior radiotherapy and recovered
• Surgery:
• See Disease Characteristics
• Prior resection of primary tumor allowed
• At least 28 days since prior surgery and recovered