Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
National Institute of Neurological Disorders and Stroke (NINDS)
The purpose of this study is to investigate the effects of flumazenil on cortical excitability in healthy human volunteers. Flumazenil acts as a potent benzodiazepine (BZP)-specific antagonist by competing at the central synaptic gamma-aminobutyric acid (GABA) receptor site. However, the relationship between GABA and flumazenil without BZPs is not well known. We plan to determine if intravenous (IV) administration in therapeutic dosage alters cortical excitability as measured by transcranial magnetic stimulation (TMS). The long-term plan is to identify a pharmacological method to reduce cortical inhibition that might be useful in stroke rehabilitation.
Age
Any age
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Only healthy volunteers, who are age 21 or older.
No history of surgery with metallic implants or known metallic particles in the brain.
Patients cannot be pregnant (as tested with a pregnancy test).
You may not be if
No history of seizures.
No cardiovascular disease or drug therapy for chronic depression.
No hypersensitivity to benzodiazepines and related drugs.
No history of drug abuse and/or chronic alcoholism.
