Combination Chemotherapy in Treating Patients With Stage III or Stage IV Ovarian Epithelial Cancer or Primary Peritoneal Cancer

Inclusion Criteria

• •Histologically confirmed stage III or IV ovarian epithelial or serous primaryperitoneal carcinoma
• •The following are ineligible:
• •* Germ cell tumors
• •* Sex cord-stromal tumors
• •* Carcinosarcomas
• •* Mixed Mullerian tumors or carcinosarcomas
• •* Metastatic carcinomas from other sites to theovary
• •* Low malignant potential tumors, including micropapillary serouscarcinomas
• •* Mucinous primary peritoneal carcinoma
• •Prior ovarian low malignant potential tumor (borderline carcinoma) that was surgically resected with subsequent development of invasive adenocarcinoma allowed if no prior chemotherapy
• •Optimal (no greater than 1 cm) or suboptimal residual disease after initial surgery
• •Prior breast cancer allowed provided the following are true:
• •* Disease-free for more than 5 years
• •* No prior cytotoxic chemotherapy for breast cancer
• •Prior or concurrent primary endometrial cancer allowed if the following conditions are met:
• •* Stage no greater than IB
• •* Less than 3 mm invasion without vascular or lymphatic invasion
• •* No poorly differentiated subtypes, including papillary serous, clear cell, or other FIGO grade 3 lesions
• •Performance status - GOG 0-2
• •Absolute neutrophil count at least 1,500/mm\^3
• •Platelet count at least 100,000/mm\^3
• •Bilirubin no greater than 1.5 times upper limit of normal (ULN)
• •AST no greater than 2.5 times ULN
• •Alkaline phosphatase no greater than 2.5 times ULN
• •No acute hepatitis
• •Creatinine no greater than 1.5 times ULN
• •No unstable angina
• •No myocardial infarction within the past 6 months
• •No evidence of abnormal cardiac conduction (e.g., bundle branch block, heart block) unless stable for the past 6 months
• •Not pregnant or nursing
• •Fertile patients must use effective contraception
• •No greater than grade 1 sensory or motor neuropathy
• •No active infection that requires antibiotics
• •No other invasive malignancy within the past 5 years except nonmelanoma skin cancer
• •No severe or ongoing gastrointestinal bleeding that requires blood product support
• •See Disease Characteristics
• •Prior chemotherapy for cancer involving the abdominal cavity or pelvis allowed provided the following are true:
• •* More than 3 years since prior therapy
• •* No evidence of recurrent disease
• •No prior radiotherapy to any portion of the abdominal cavity or pelvis
• •Prior radiotherapy for localized breast, head and neck, or skin cancer allowed provided the following are true:
• •* More than 3 years since prior therapy
• •* No evidence of recurrent disease
• •See Disease Characteristics
• •No more than 12 weeks since prior surgical resection