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NQO1 in Protection Against Benzene Toxicity
We are investigating the role of an enzyme (NQO1) in protection against the bone marrow toxicity of the occupational and environmental toxicant benzene. All of the proposed studies involve use of human bone marrow cells in-vitro to define mechanisms of NQO1-mediated protection. Cells are obtained from healthy volunteers and protocols have undergone IRB review and approval.
Age
21 - 65 years
Sex
ALL
Healthy Volunteers
Yes
University of Colorado Health Sciences Center
Denver, Colorado, United States
Start Date
July 1, 1998
Completion Date
June 1, 2001
Last Updated
June 24, 2005
Lead Sponsor
National Institute of Environmental Health Sciences (NIEHS)
NCT00106925
NCT07388563
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