Benzoylphenylurea in Treating Patients With Advanced Cancer

You may be eligible if

• Histologically confirmed malignancy
• * Metastatic or unresectable
• * No standard curative or palliative measures exist or are ineffective
• Brain metastases allowed provided 1 of the following criteria is met:
• * Lesions were previously treated with surgery, radiotherapy, or chemotherapy AND are currently asymptomatic AND no steroid therapy or antiseizure medication within the past 2 weeks
• * Untreated, asymptomatic metastases AND no requirement for steroid therapy or antiseizure medication
• Performance status - ECOG 0-2
• More than 12 weeks
• WBC at least 3,000/mm\^3
• Absolute neutrophil count at least 1,500/mm\^3
• Platelet count at least 100,000/mm\^3
• Bilirubin normal
• SGOT/SGPT no greater than 2.5 times upper limit of normal
• Albumin at least 3.0 mg/dL
• Creatinine normal
• Creatinine clearance at least 60 mL/min
• No symptomatic congestive heart failure, unstable angina pectoris, or cardiac arrhythmia
• No prior allergic reactions to compounds of similar chemical or biologic composition to benzoylphenylurea
• No neuropathy greater than grade 1
• No other uncontrolled medical or psychiatric illness that would preclude study compliance
• No ongoing or active infection
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• Prior immunotherapy allowed
• No concurrent filgrastim (G-CSF) or sargramostim (GM-CSF)
• At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas and mitomycin) and recovered
• At least 2 weeks since steroids for CNS disease
• At least 4 weeks since prior radiotherapy and recovered
• Prior surgery allowed
• At least 2 weeks since antiseizure medications for CNS disease
• More than 7 days since prior CYP3A4 or CYP2D6 inhibitors
• More than 7 days since prior CYP3A4 inducers
• No concurrent CYP3A4 or CYP2D6 inhibitors
• No concurrent CYP3A4 inducers
• No other concurrent investigational agents
• No concurrent combination anti-retroviral therapy for HIV