Finding studies
Finding studies
Take this into the appointment.
Saves the questions and what to expect into your notes, next to the visit they belong to.
Lead
University of Pittsburgh
With
OBJECTIVES: * Determine the toxic effects and maximum tolerated dose of calcitriol when combined with paclitaxel in patients with advanced solid tumors. * Determine the effect of administration of calcitriol on the pharmacokinetics of paclitaxel in these patients. * Determine the effect of administration of paclitaxel on the pharmacokinetics of calcitriol in these patients. OUTLINE: This is a dose-escalation study of calcitriol. During course 1, patients receive oral calcitriol daily on days 1-3 of weeks 1-6 and paclitaxel IV over 1 hour on day 1 of week 1 and day 3 of weeks 2-6. During course 2 and subsequent courses, patients receive oral calcitriol daily on days 1-3 and paclitaxel IV over 1 hour on day 3 of weeks 1-6. Treatment continues every 8 weeks in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients receive escalating doses of calcitriol until the maximum tolerated dose (MTD) is determined. The MTD is defined as the highest dose giving an estimated probability of dose-limiting toxicity of no more than 0.30. PROJECTED ACCRUAL: A total of 60 patients will be accrued for this study.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted