MRI-Guided Ultrasound Energy in Treating Patients With Stage I, Stage II, or Stage IIIA Breast Cancer

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Histologically confirmed invasive breast cancer (T1, N0-2, M0)
• •Single focal lesion no greater than 3.5 cm in diameter by MRI
• •No lesions difficult to target, defined as less than 1 cm from skin, nipple, or rib cage
• •No microcalcifications as sole sign of disease
• •No extensive intraductal components on core biopsy, defined as intraductal carcinoma comprising 25% or more of the invasive breast cancer AND intraductal carcinoma in surrounding normal tissue
• •No breast implants
• •Hormone receptor status:
• •* Not specified
• •PATIENT CHARACTERISTICS:
• •Age:
• •18 and over
• •Sex:
• •Female
• •Menopausal status:
• •Not specified
• •Performance status:
• •Karnofsky 80-100%
• •Life expectancy:
• •At least 5 years
• •Hematopoietic:
• •No hemolytic anemia (hematocrit less than 30%)
• •Hepatic:
• •Not specified
• •Renal:
• •Not specified
• •Cardiovascular:
• •No heart disease
• •No unstable angina pectoris requiring medication
• •No myocardial infarction within the past 6 months
• •No congestive heart failure requiring medication
• •No diastolic blood pressure greater than 100 mm Hg while receiving medication to treat hypertension
• •No cerebrovascular accident (CVA) within the past 6 months
• •No multiple CVAs
• •No cardiac pacemakers
• •Pulmonary:
• •No chronic obstructive pulmonary disease
• •No other lung disease
• •No sleep apnea or airway problems
• •No severe asthma
• •Other:
• •Not pregnant or nursing
• •Fertile patients must use effective contraception
• •No contraindications to MRI (e.g., implanted medical devices)
• •Must be able to lie prone and still for up to 150 minutes
• •Weight no greater than 250 pounds
• •No severe arthritis
• •No severe claustrophobia
• •No grand mal seizures
• •No insulin-dependent diabetes mellitus
• •No prior reaction to gadolinium-based contrast agent
• •Able to communicate sensations during procedure
• •PRIOR CONCURRENT THERAPY:
• •Biologic therapy:
• •Not specified
• •Chemotherapy:
• •At least 3 months since prior chemotherapy
• •Endocrine therapy:
• •Concurrent hormone replacement therapy allowed
• •Concurrent tamoxifen allowed
• •No concurrent steroids
• •Radiotherapy:
• •No prior external radiotherapy or laser therapy to ipsilateral breast
• •Surgery:
• •See Disease Characteristics
• •Other:
• •No concurrent anti-arrhythmic drugs
• •No concurrent immunosuppressive medication
• •No concurrent anticoagulation therapy
• •No concurrent dialysis