Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Histologically or cytologically confirmed solid tumors
• •* Neuroblastoma
• •* Ewing's sarcoma/peripheral primitive neuroectodermal tumor (PNET)(Ewing's sarcoma closed to accrual as of 5/19/03)
• •* Osteosarcoma (closed to accrual as of 5/19/03)
• •* Rhabdomyosarcoma
• •* Other extracranial solid tumors
• •* CNS/brain tumors:
• •* Medulloblastoma/PNET
• •* Ependymoma
• •* Brainstem glioma
• •* Other CNS tumors
• •* Histological verification may be waived for brainstem glioma and classic optic glioma, but biopsy recommended OR
• •Histologically or cytologically proven non-Hodgkin's lymphoma
• •* Refractory to standard treatment and no curative therapy available
• •Measurable disease
• •PATIENT CHARACTERISTICS:
• •Age:
• •21 and under at time of original diagnosis
• •Performance status:
• •Karnofsky 50-100% in patients over 10 years of age
• •Lansky 50-100% in patients age 10 and under
• •Life expectancy:
• •At least 8 weeks
• •Hematopoietic:
• •Absolute neutrophil count greater than 1,000/mm\^3
• •Platelet count greater than 75,000/mm\^3
• •Hemoglobin greater than 8.0 g/dL
• •Hepatic:
• •Bilirubin normal for age
• •SGPT less than 2.5 times upper limit of normal
• •Amylase normal
• •Lipase normal
• •Renal:
• •Creatinine normal for age OR
• •Glomerular filtration rate at least 60 mL/min
• •Other:
• •No concurrent uncontrolled infection
• •Not pregnant or nursing
• •Negative pregnancy test
• •Fertile patients must use effective contraception during and for 6 months after study participation
• •PRIOR CONCURRENT THERAPY:
• •Biologic therapy:
• •Recovered from prior immunotherapy
• •Chemotherapy:
• •At least 6 weeks since prior nitrosourea and recovered
• •Recovered from any other prior chemotherapy
• •No more than two prior chemotherapy regimens
• •Endocrine therapy:
• •CNS tumor patients receiving dexamethasone must be on stable or decreasing dose at least 2 weeks prior to study entry
• •Radiotherapy:
• •At least 6 weeks since prior extended radiotherapy and recovered
• •No prior total body irradiation
• •Surgery:
• •Prior radiosurgery allowed
• •Other:
• •No concurrent use of the following foods or medications:
• •* Grapefruit juice
• •* Erythromycin
• •* Azithromycin
• •* Clarithromycin
• •* Rifampin and analogues
• •* Fluconazole
• •* Ketoconazole
• •* Itraconazole
• •* Cimetidine
• •* Cannabinoids (marijuana or dronabinol)
• •* Leukotriene inhibitors (e.g., zafirlukast and zileuton)
• •No other concurrent anticancer or investigational agents