Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically or cytologically confirmed solid tumors
• * Neuroblastoma
• * Ewing's sarcoma/peripheral primitive neuroectodermal tumor (PNET)(Ewing's sarcoma closed to accrual as of 5/19/03)
• * Osteosarcoma (closed to accrual as of 5/19/03)
• * Rhabdomyosarcoma
• * Other extracranial solid tumors
• * CNS/brain tumors:
• * Medulloblastoma/PNET
• * Ependymoma
• * Brainstem glioma
• * Other CNS tumors
• * Histological verification may be waived for brainstem glioma and classic optic glioma, but biopsy recommended OR
• Histologically or cytologically proven non-Hodgkin's lymphoma
• * Refractory to standard treatment and no curative therapy available
• Measurable disease
• PATIENT CHARACTERISTICS:
• Age:
• 21 and under at time of original diagnosis
• Performance status:
• Karnofsky 50-100% in patients over 10 years of age
• Lansky 50-100% in patients age 10 and under
• Life expectancy:
• At least 8 weeks
• Hematopoietic:
• Absolute neutrophil count greater than 1,000/mm\^3
• Platelet count greater than 75,000/mm\^3
• Hemoglobin greater than 8.0 g/dL
• Hepatic:
• Bilirubin normal for age
• SGPT less than 2.5 times upper limit of normal
• Amylase normal
• Lipase normal
• Renal:
• Creatinine normal for age OR
• Glomerular filtration rate at least 60 mL/min
• Other:
• No concurrent uncontrolled infection
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception during and for 6 months after study participation
• PRIOR CONCURRENT THERAPY:
• Biologic therapy:
• Recovered from prior immunotherapy
• Chemotherapy:
• At least 6 weeks since prior nitrosourea and recovered
• Recovered from any other prior chemotherapy
• No more than two prior chemotherapy regimens
• Endocrine therapy:
• CNS tumor patients receiving dexamethasone must be on stable or decreasing dose at least 2 weeks prior to study entry
• Radiotherapy:
• At least 6 weeks since prior extended radiotherapy and recovered
• No prior total body irradiation
• Surgery:
• Prior radiosurgery allowed
• Other:
• No concurrent use of the following foods or medications:
• * Grapefruit juice
• * Erythromycin
• * Azithromycin
• * Clarithromycin
• * Rifampin and analogues
• * Fluconazole
• * Ketoconazole
• * Itraconazole
• * Cimetidine
• * Cannabinoids (marijuana or dronabinol)
• * Leukotriene inhibitors (e.g., zafirlukast and zileuton)
• No other concurrent anticancer or investigational agents