S9927 Radiation Therapy After Surgery, Chemotherapy, and/or Hormone Therapy in Stage II Breast Cancer

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Histologically confirmed stage II adenocarcinoma of the breast (T1-2, N1, M0)
• •* Primary tumor no greater than 5 cm
• •* At least 1 but no more than 3 positive axillary lymph nodes
• •* Nodes cannot be positive solely by cytokeratin staining
• •* No apocrine, adenocystic, or squamous cell carcinomas or sarcomas of the breast
• •* No bilateral breast cancer
• •* No active local regional disease
• •Must have undergone a modified radical mastectomy with a level I and II with or without a level III axillary dissection (at least 10 nodes examined) within the past 8 months
• •* Surgical margins negative for invasive and noninvasive ductal carcinoma
• •* No gross extracapsular disease or residual disease in the axilla
• •* Microscopic extracapsular extension allowed
• •No mastectomy after local failure following lumpectomy
• •Must have received adjuvant chemotherapy and/or hormonal therapy after mastectomy
• •Hormone receptor status:
• •* Not specified
• •PATIENT CHARACTERISTICS:
• •Age:
• •21 and over
• •Sex:
• •Female
• •Menopausal status:
• •Pre- or post-menopausal
• •Performance status:
• •Zubrod 0-1
• •Life expectancy:
• •Not specified
• •Hematopoietic:
• •Not specified
• •Hepatic:
• •Not specified
• •Renal:
• •Not specified
• •Other:
• •Not pregnant or nursing
• •Fertile patients must use effective contraception
• •No other prior malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix
• •No serious medical or psychiatric illness that would preclude study compliance
• •PRIOR CONCURRENT THERAPY:
• •Biologic therapy:
• •No prior trastuzumab (Herceptin)
• •Chemotherapy:
• •See Disease Characteristics
• •No more than 6 weeks since prior adjuvant chemotherapy
• •No other prior chemotherapy
• •Concurrent adjuvant chemotherapy allowed
• •Endocrine therapy:
• •See Disease Characteristics
• •Concurrent adjuvant hormonal therapy allowed
• •Radiotherapy:
• •No prior chest wall or nodal radiotherapy
• •Surgery:
• •See Disease Characteristics
• •Breast reconstruction allowed
• •Other:
• •Concurrent registration on another adjuvant chemotherapy or hormonal therapy study is allowed