Combination Chemotherapy in Treating Patients With Advanced Ovarian Epithelial Cancer

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically confirmed advanced ovarian epithelial carcinoma, regardless of quantity of disease post-surgery
• * Stage IC, II, III, or IV
• PATIENT CHARACTERISTICS:
• Age:
• 18 and over
• Performance status:
• ECOG 0-2
• Life expectancy:
• Not specified
• Hematopoietic:
• Absolute neutrophil count at least 1,500/mm\^3
• Platelet count at least 100,000/mm\^3
• Hepatic:
• SGOT no greater than 3 times upper limit of normal
• Bilirubin no greater than 2.0 mg/dL
• No clinically significant hepatic disorder
• Renal:
• Creatinine no greater than 1.5 mg/dL OR
• Creatinine clearance greater than 60 mL/min
• No clinically significant renal disorder
• Cardiovascular:
• No clinically significant cardiovascular condition
• Other:
• Normal GI function allowing reliable administration of oral medication
• No active infection requiring systemic medical therapy within past week
• No other clinically significant medical condition (e.g., endocrine/metabolic or autoimmune disorder)
• No other prior malignancy within the past 5 years except nonmelanoma skin cancer or carcinoma in situ of the cervix
• No dementia or altered mental status that would preclude consent
• Not pregnant
• Fertile patients must use effective contraception
• PRIOR CONCURRENT THERAPY:
• Biologic therapy:
• Not specified
• Chemotherapy:
• No prior chemotherapy for ovarian epithelial carcinoma
• Endocrine therapy:
• Not specified
• Radiotherapy:
• No prior radiotherapy for ovarian epithelial carcinoma
• Surgery:
• See Disease Characteristics