Sarcosinamide Nitrosourea in Treating Patients With Metastatic or Unresectable Solid Tumors

You may be eligible if

• Histologically documented malignancy, which is either metastatic or inoperable, for which there is no known curative or standard palliative therapy, or all standard therapeutic approaches have failed
• Patients with leukemia or primary CNS malignancies are excluded; patients with metastatic disease to the CNS, who are not receiving anticonvulsants, including phenytoin, carbamazepine, phenobarbital, primidone, and felbamate, and who have reasonable expectation of surviving long enough to receive two cycles of therapy, are eligible
• Life expectancy of 2 months or longer
• ECOG performance status of 0-2
• Pretreatment laboratory data, obtained within 14 days of study entry, must meet the following criteria:
• ANC \>= 1,500 /mm\^3
• Platelets \>= 100,000 /mm\^3
• SGOT =\< 2.5-times upper limit of normal
• SGPT =\< 2.5-times upper limit of normal
• Total bilirubin =\< upper limit of normal
• Creatinine =\< 1.5 mg/dl
• Creatinine CL \>= 60 ml/min (measured 24hr) if creatinine \> 1.5 mg/dl
• DLCO \>= 80% predicted
• At least 4 weeks since last receiving radiotherapy or chemotherapy and complete recovery from previous treatment related toxicity
• No prior treatment with a nitrosourea or with bleomycin
• No enzyme inducing anticonvulsant agents
• At least 2 weeks since major surgery
• Patients must not have uncontrolled serious medical or psychiatric illness
• Women of childbearing potential must not be lactating or pregnant, because of the proven teratogenicity of other agents of this class; a negative pregnancy test has to be obtained within 2 weeks of entry; both fertile males and females must use adequate contraception upon entry into the study
• Patients must have given signed informed consent