S9912 Combination Chemo in Stage III Ovarian Cancer,

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Histologically confirmed stage III ovarian epithelial, fallopian tube, or primary peritoneal carcinoma
• •* Tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside the pelvis and/or regional lymph node metastasis
• •* No tumors of borderline or low malignant potential only
• •* Mixed Mullerian tumors allowed
• •Must have optimal disease defined as no residual lesions after resection or residual disease such that no single lesion measures greater than 1 cm in diameter
• •Must have undergone staging exploratory laparotomy with tumor debulking within the past 70 days
• •PATIENT CHARACTERISTICS:
• •Age:
• •Not specified
• •Performance status:
• •SWOG 0-1
• •Life expectancy:
• •Not specified
• •Hematopoietic:
• •Granulocyte count ≥ 1,500/mm\^3
• •Platelet count ≥ 100,000/mm\^3
• •Hepatic:
• •Bilirubin ≤ 2 times upper limit of normal (ULN)
• •SGOT or SGPT ≤ 2 times ULN
• •Renal:
• •Creatinine clearance ≥ 50 mL/min
• •Cardiovascular:
• •No congestive heart failure
• •No cardiac arrhythmia
• •No myocardial infarction or unstable angina within the past 6 months
• •Patients with a history of myocardial disease must not have ischemia or pathologic arrhythmias and must have an ejection fraction \> 50% by MUGA
• •Other:
• •Not pregnant or nursing
• •Fertile patients must use effective contraception
• •No active or uncontrolled infection
• •No concurrent fever
• •No grade 2 or greater sensory neuropathy
• •No severe gastrointestinal symptoms (i.e., partial obstruction) and/or bleeding, diarrhea, or abdominal tenderness suggestive of peritoneal irritation or infection
• •No erythema or tenderness of abdominal incision or port site suggestive of underlying infection
• •No other malignancy within the past five years except adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix
• •PRIOR CONCURRENT THERAPY:
• •Biologic therapy:
• •No prior immunotherapy for ovarian cancer
• •Chemotherapy:
• •No prior chemotherapy for ovarian cancer
• •Endocrine therapy:
• •Not specified
• •Radiotherapy:
• •No prior pelvic radiotherapy for ovarian cancer
• •Surgery:
• •See Disease Characteristics
• •Recovered from all reversible surgery-related toxic effects
• •Other:
• •No other concurrent antitumor treatment
• •No concurrent antibiotics for infection of undetermined etiology