S9912 Combination Chemo in Stage III Ovarian Cancer,

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically confirmed stage III ovarian epithelial, fallopian tube, or primary peritoneal carcinoma
• * Tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside the pelvis and/or regional lymph node metastasis
• * No tumors of borderline or low malignant potential only
• * Mixed Mullerian tumors allowed
• Must have optimal disease defined as no residual lesions after resection or residual disease such that no single lesion measures greater than 1 cm in diameter
• Must have undergone staging exploratory laparotomy with tumor debulking within the past 70 days
• PATIENT CHARACTERISTICS:
• Age:
• Not specified
• Performance status:
• SWOG 0-1
• Life expectancy:
• Not specified
• Hematopoietic:
• Granulocyte count ≥ 1,500/mm\^3
• Platelet count ≥ 100,000/mm\^3
• Hepatic:
• Bilirubin ≤ 2 times upper limit of normal (ULN)
• SGOT or SGPT ≤ 2 times ULN
• Renal:
• Creatinine clearance ≥ 50 mL/min
• Cardiovascular:
• No congestive heart failure
• No cardiac arrhythmia
• No myocardial infarction or unstable angina within the past 6 months
• Patients with a history of myocardial disease must not have ischemia or pathologic arrhythmias and must have an ejection fraction \> 50% by MUGA
• Other:
• Not pregnant or nursing
• Fertile patients must use effective contraception
• No active or uncontrolled infection
• No concurrent fever
• No grade 2 or greater sensory neuropathy
• No severe gastrointestinal symptoms (i.e., partial obstruction) and/or bleeding, diarrhea, or abdominal tenderness suggestive of peritoneal irritation or infection
• No erythema or tenderness of abdominal incision or port site suggestive of underlying infection
• No other malignancy within the past five years except adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix
• PRIOR CONCURRENT THERAPY:
• Biologic therapy:
• No prior immunotherapy for ovarian cancer
• Chemotherapy:
• No prior chemotherapy for ovarian cancer
• Endocrine therapy:
• Not specified
• Radiotherapy:
• No prior pelvic radiotherapy for ovarian cancer
• Surgery:
• See Disease Characteristics
• Recovered from all reversible surgery-related toxic effects
• Other:
• No other concurrent antitumor treatment
• No concurrent antibiotics for infection of undetermined etiology