Dolastatin 10 in Treating Patients With Recurrent or Metastatic Soft Tissue Sarcoma

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Histologically proven recurrent or metastatic soft tissue sarcoma
• •No rhabdomyosarcoma, Ewing's sarcoma, chondrosarcoma, osteogenic sarcoma, mesothelioma, or Kaposi's sarcoma Bidimensionally measurable disease other than previously irradiated disease site(s) even if there has been progression within the radiation field
• •Pulmonary nodule(s) at least 1 x 1 cm No brain metastases
• •PATIENT CHARACTERISTICS:
• •Age: 18 and over
• •Performance status: ECOG 0 or 1
• •Absolute neutrophil count at least 2,000/mm3
• •Platelet count at least 100,000/mm3
• •Bilirubin no greater than 1.5 mg/dL
• •AST and ALT less than 1.5 times upper limit of normal (ULN) (3 times ULN if liver metastases present)
• •Creatinine no greater than 1.5 mg/dL
• •Not pregnant or nursing
• •Negative pregnancy test
• •Fertile patients must use effective contraception during and for 3 months after study
• •No uncontrolled infection
• •No history of prior malignancy within the past 5 years except basal cell or squamous cell skin cancer, carcinoma in situ of the cervix, or any other malignancy in complete remission
• •PRIOR CONCURRENT THERAPY:
• •No more than 1 prior chemotherapy regimen in the adjuvant setting
• •No prior chemotherapy for metastatic disease
• •At least 4 weeks since prior chemotherapy (6 weeks for mitomycin or nitrosoureas)
• •At least 4 weeks since prior radiotherapy
• •Recovered from prior surgery