Combination Chemotherapy With or Without G-CSF in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Histologically confirmed primary stage III, stage IV, or recurrent endometrial carcinoma
• •* Very poor potential for cure by radiotherapy or surgery alone or in combination
• •Measurable disease
• •* Disease in an irradiated field as the only site of measurable disease allowed provided there has been clear progression since completion of radiotherapy
• •PATIENT CHARACTERISTICS:
• •Age
• •18 and over
• •Performance status
• •GOG 0-2
• •Life expectancy
• •Not specified
• •Hematopoietic
• •Platelet count at least 100,000/mm\^3
• •Granulocyte count at least 1,500/mm\^3
• •Hepatic
• •SGPT no greater than 3 times upper limit of normal
• •Bilirubin normal
• •Renal
• •Creatinine no greater than 1.6 mg/dL
• •Cardiovascular
• •LVEF at least 50% within past 6 months
• •No uncontrolled angina
• •No third-degree or complete heart block unless a pacemaker is in place
• •Neurologic
• •No serious peripheral neuropathy
• •Other
• •No prior or concurrent malignancy within past 5 years except nonmelanoma skin cancer
• •No uncontrolled infection
• •No sensitivity to E. coli-derived drug preparations
• •PRIOR CONCURRENT THERAPY:
• •Biologic therapy
• •Prior biologic therapy allowed
• •No concurrent biologic therapy
• •Chemotherapy
• •No prior cytotoxic chemotherapy, including chemotherapy used for radiation sensitization
• •No prior chemotherapy for any prior malignancy
• •Endocrine therapy
• •Prior hormone therapy allowed
• •No concurrent hormone therapy
• •Radiotherapy
• •At least 4 weeks since prior radiotherapy to the whole pelvis or to over 50% of the spine
• •Surgery
• •Not specified