Antineoplaston Therapy in Treating Patients With Stage IV Cancer of the Cervix and/or Vulva

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically proven incurable stage IV carcinoma of the uterine cervix and/or vulva that is unlikely to respond to existing therapy
• Measurable disease by MRI or CT scan
• Tumor must be at least 2 cm
• PATIENT CHARACTERISTICS:
• Age:
• 18 and over
• Performance status:
• Karnofsky 60-100%
• Life expectancy:
• At least 2 months
• Hematopoietic:
• WBC at least 2,000/mm\^3
• Platelet count at least 50,000/mm\^3
• Hepatic:
• No hepatic insufficiency
• Bilirubin no greater than 2.5 mg/dL
• SGOT and SGPT no greater than 5 times upper limit of normal
• Renal:
• No renal insufficiency
• Creatinine no greater than 2.5 mg/dL
• No history of renal conditions that contraindicate high dosages of sodium
• Cardiovascular:
• No known chronic heart failure
• No uncontrolled hypertension
• No history of congestive heart failure
• No history of other cardiovascular conditions that contraindicate high dosages of sodium
• Pulmonary:
• No serious lung disease, such as chronic obstructive pulmonary disease
• Other:
• Not pregnant or nursing
• Fertile patients must use effective contraception
• Not a high medical or psychiatric risk
• No concurrent nonmalignant systemic disease
• No active infection
• PRIOR CONCURRENT THERAPY:
• Biologic therapy:
• At least 4 weeks since prior immunotherapy and recovered
• No concurrent immunomodulatory agents
• Chemotherapy:
• At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas) and recovered
• Endocrine therapy:
• At least 1 month since prior tamoxifen if no progression
• * May enter study immediately if evidence of progression
• Concurrent corticosteroids allowed
• Radiotherapy:
• At least 8 weeks since prior radiotherapy and recovered
• Surgery:
• Recovered from prior surgery
• Other:
• Prior cytodifferentiating agents allowed
• No prior antineoplastons
• No other concurrent antineoplastic agents