Biological Therapy in Stage I, Stage II, or Stage III Surgically Resected Pancreatic Cancer

You may be eligible if

• Disease Characteristics:
• Histologically confirmed stage I, II, or III adenocarcinoma of the pancreas Resected with no gross residual disease At least 50% of tumor cells must be CEA positive and stain with at least moderate intensity HLA-A2 positive
• Patient Characteristics:
• Age: 18 and over
• Performance status: Karnofsky 70-100%
• Life expectancy: Greater than 6 months
• Hematopoietic: Absolute neutrophil count at least 1000/mm3
• Hepatic: Bilirubin less than 2.0 mg/dL SGOT and alkaline phosphatase less than 4 times the upper limit of normal No hepatic failure
• Renal: Creatinine less than 2.0 mg/dL OR Creatinine clearance greater than 50 mL/min
• Cardiovascular: No New York Heart Association class III or IV heart disease
• Pulmonary: No concurrent asthma or chronic obstructive pulmonary disease
• Other:
• No other malignancy except nonmelanoma skin cancer or controlled superficial bladder cancer within the past 5 years.
• No history of autoimmune diseases such as inflammatory bowel disease, systemic lupus erythematosus, ankylosing spondylitis, scleroderma, rheumatoid arthritis, or multiple sclerosis
• No active acute or chronic infection such as urinary tract infection, HIV, or viral hepatitis
• No active infectious enteritis or eosinophilic enteritis Not pregnant or nursing Fertile patients must use effective contraception
• Prior Therapy:
• Biologic therapy: At least 4 weeks since immunotherapy. No other concurrent immunotherapy
• Chemotherapy: At least 4 weeks since chemotherapy and recovered. No concurrent chemotherapy
• Endocrine therapy: No concurrent corticosteroid or immunosuppressive therapy. At least 6 weeks since steroid therapy
• Radiotherapy: At least 4 weeks since radiotherapy and recovered
• Surgery: Recovered from prior surgery