Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Peripheral Blood Stem Cell Transplant Followed by Donor Lymphocyte Infusion in Treating Older Patients With Chronic Myeloid Leukemia

Exclusion Criteria

• •Patients who are human immunodeficiency virus positive (HIV+)
• •GROUP 1: (PATIENTS AGED \> 65 AND \< 75 YEARS)
• •Patients unwilling to use contraceptive techniques during and for 12 months following treatment
• •Presence of circulating leukemic blasts (in the peripheral blood) detected by standard pathology for patients with CML
• •Patients in an interferon induced complete or partial cytogenetic remission
• •Organ dysfunction:
• •* Patients with renal failure are eligible, however patients with renal compromise (Serum creatinine greater than 2.0) will likely have further compromise in renal function and may require hemodialysis (which may be permanent) due to the need to maintain adequate serum cyclosporine levels
• •* Cardiac ejection fraction \< 40%; ejection fraction is required if the patient has a history of anthracyclines or history of cardiac disease
• •* Diffusing capacity of the lung for carbon monoxide (DLCO) \< 50% of predicted
• •* Liver function tests including total bilirubin, serum glutamic pyruvate transaminase (SGPT) and serum glutamic oxaloacetic transaminase (SGOT) \> 2x the upper limit of normal unless proven to be due to the malignancy
• •* Karnofsky score \< 70
• •Patients with poorly controlled hypertension
• •GROUP 2 (PATIENTS AGED =\< 65)
• •Patients who are HIV+
• •Presence of circulating leukemic blasts (in the peripheral blood) detected by standard pathology for patients with CML
• •Females who are pregnant
• •Patients unwilling to use contraceptive techniques during and for 12 months following treatment
• •Patients in an interferon induced complete or partial cytogenetic remission
• •Organ dysfunction:
• •* Patients with renal failure are eligible, however patients with renal compromise (Serum creatinine greater than 2.0) will likely have further compromise in renal function and may require hemodialysis (which may be permanent) due to the need to maintain adequate serum cyclosporine levels
• •* Cardiac ejection fraction \< 40% or a history of congestive heart failure; ejection fraction is required if the patient has a history of anthracyclines or history of cardiac disease
• •* Severe defects in pulmonary function testing as defined by the pulmonary consultant (defects are currently categorized as mild, moderate and severe) or receiving supplementary continuous oxygen; DLCO \< 50% of predicted
• •* Liver function tests: total bilirubin \> 2x the upper limit of normal, SGPT and SGOT 4x the upper limit of normal
• •* Karnofsky score \< 50
• •Patients with poorly controlled hypertension
• •DONOR: Age less than 12 years
• •DONOR: Pregnancy
• •DONOR: Infection with HIV
• •DONOR: Inability to achieve adequate venous access
• •DONOR: Known allergy to G-CSF
• •DONOR: Current serious systemic illness