Paclitaxel in Treating Older Patients With Solid Tumors

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Histologically proven nonhematologic malignancy
• •PATIENT CHARACTERISTICS:
• •Age:
• •55 and over
• •Performance status:
• •Zubrod 0-2
• •Life expectancy:
• •Not specified
• •Hematopoietic:
• •Granulocyte count at least 1,500/mm3
• •Platelet count at least 100,000/mm3
• •Hepatic:
• •Bilirubin less than 1.5 mg/dL
• •SGOT less than 2.0 times upper limit of normal (ULN)
• •Renal:
• •Creatinine no greater than 1.5 times ULN
• •Cardiovascular:
• •No uncontrolled or severe cardiovascular disease
• •Other:
• •No serious intercurrent medical illnesses that in the judgement of the investigator compromise patient care
• •No psychiatric conditions that would preclude study
• •No requirement for antibiotics for active acute infection
• •PRIOR CONCURRENT THERAPY:
• •Biologic therapy:
• •Not specified
• •Chemotherapy:
• •At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin)
• •No more than one prior chemotherapy regimen allowed
• •No prior paclitaxel allowed
• •Endocrine therapy:
• •Not specified
• •Radiotherapy:
• •At least 4 weeks since prior radiation therapy
• •Surgery:
• •Not specified