Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Alliance for Clinical Trials in Oncology
With
National Cancer Institute (NCI)
OBJECTIVES:
* Determine whether there is a relationship between pharmacokinetic measurements of paclitaxel and aging.
* Determine whether there is a relationship between the toxic effects of paclitaxel and aging.
OUTLINE: Patients are stratified according to age (cohort 1: patients 55 to 64 vs cohort 2: patients 65 to 75 vs cohort 3: patients 75 and over).
Age
55–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
DISEASE CHARACTERISTICS:
Histologically proven nonhematologic malignancy
PATIENT CHARACTERISTICS:
Age:
55 and over
Performance status:
Zubrod 0-2
Life expectancy:
Not specified
Hematopoietic:
Granulocyte count at least 1,500/mm3
Platelet count at least 100,000/mm3
Hepatic:
Bilirubin less than 1.5 mg/dL
SGOT less than 2.0 times upper limit of normal (ULN)
Renal:
Creatinine no greater than 1.5 times ULN
Cardiovascular:
No uncontrolled or severe cardiovascular disease
Other:
No serious intercurrent medical illnesses that in the judgement of the investigator compromise patient care
No psychiatric conditions that would preclude study
No requirement for antibiotics for active acute infection
PRIOR CONCURRENT THERAPY:
Biologic therapy:
Not specified
Chemotherapy:
At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin)
No more than one prior chemotherapy regimen allowed
No prior paclitaxel allowed
Endocrine therapy:
Not specified
Radiotherapy:
At least 4 weeks since prior radiation therapy
Surgery:
Not specified
Clareo Health | Paclitaxel in Treating Older Patients With Solid Tumors