Flavopiridol in Treating Patients With Recurrent Intermediate-Grade or High-Grade Non-Hodgkin's Lymphoma or Mantle Cell Lymphoma

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically confirmed intermediate or high grade non-Hodgkin's lymphoma (NHL) and mantle cell lymphoma with clinical or pathological evidence of recurrent disease
• Measurable or evaluable disease
• CNS metastases not requiring intravenous steroid therapy allowed
• PATIENT CHARACTERISTICS:
• Age: 18 and over
• Performance status: CALGB 0-2
• Life expectancy: At least 12 weeks
• Absolute neutrophil count at least 1500/mm3 (unless due to bone marrow involvement by lymphoma)
• Platelet count at least 100,000/mm3 (unless due to bone marrow involvement by lymphoma)
• At least 7 days since platelet transfusion
• Hemoglobin at least 9.0 g/dL
• Bilirubin no greater than 1.5 mg/dL
• Transaminases no greater than 2.5 times upper limit of normal
• Creatinine no greater than 1.5 mg/dL OR creatinine clearance at least 60 mL/min
• No significant uncontrolled medical or psychiatric illness
• No active serious infection
• Not pregnant or lactating
• Fertile patients must use effective contraception
• Central venous catheter required prior to study entry
• PRIOR CONCURRENT THERAPY:
• No more than 1 prior chemotherapy regimen
• At least 4 weeks since prior chemotherapy and recovered from all toxic effects Prior chemotherapy must contain anthracycline if intermediate or high-grade NHL other than mantle cell
• No concurrent treatment with other chemotherapeutic or investigational antineoplastic drugs
• At least 4 weeks since prior radiation therapy and recovered (Site of only measurable disease must not be located within prior radiation therapy port)
• No concurrent radiation therapy to any lesion