Interleukin-2 or Observation Following Radiation Therapy, Combination Chemotherapy, and Peripheral Stem Cell Transplantation in Treating Patients With Recurrent Non-Hodgkin's Lymphoma

Patients must have relapsed after achieving a complete or partial response to prior therapy, or have never responded to prior therapy

Patients must have debulking (salvage) chemotherapy to determine if the disease is sensitive to chemotherapy; the sole exception to this requirement is for patients with intermediate or high grade lymphoma (working formulation D - H or J) whose disease did not respond to, or progressed during, INITIAL chemotherapy

Prior therapy is required; concurrent therapy is NOT permitted

* Patients with low grade lymphoma (working formulation B or C) must have received at least two prior chemotherapy regimens; if the patient has had one or more CR, then the most recent CR must have been less than one year in duration

* Patients with intermediate or high grade non-Hodgkin's lymphoma (working formulation D - H or J) must have received at least one prior chemotherapy regimen

* NOTE: Debulking chemotherapy given only to determine sensitivity is not considered in the calculation of number of prior regimens

Patients must have a bone marrow aspirate and biopsy obtained within 42 days of stem cell collection or within 42 days prior to registration

Only patients with a normal cardiac history and physical exam or in lieu of this, an institutionally normal ejection fraction as measured by either ECHO or MUGA scan are eligible; specifically, there should be: no EKG evidence of active cardiac disease (i.e., arrhythmias, ischemia), no history of congestive heart failure (CHF), no history of myocardial infarction or ischemia, no history of arrhythmia (other than bradycardia treated by pacing), no current cardiac medications for the control of CHF or arrhythmias, no S3 gallop rhythm, or peripheral edema, and no chest X-ray findings compatible with CHF; EKG must be performed within 42 days prior to registration

All patients must have a pretreatment serum creatinine of =\< 1.5 times the institutional upper limit of normal measured after completion of prior therapy and within 28 days prior to registration

Patients must have adequate pulmonary function as measured by a DLCO \>= 65% of predicted or FEV1 \>= 65% of predicted measured after completion of prior therapy and within 120 days prior to registration

Patients must have adequate hepatic function as measured by a bilirubin of =\< 1.5 x the institutional upper limit of normal and SGOT or SGPT =\< 2 x the institutional upper limit of normal, measured after completion of prior therapy and within 28 days prior to registration

Patients must have recovered from the nadir resulting from the last cancer therapy; this will generally be at least four weeks from prior radiation or chemotherapy, and six weeks from nitrosoureas

Patients must have a Southwest Oncology Group performance status of 0 or 1

Patients must have a CT scan of the chest, abdomen and pelvis performed within 28 days prior to registration and at least 21 days after the completion of prior chemotherapy (excluding mobilization therapy)

Patients must have LDH performed within 28 days prior to registration and at least 21 days after completion of prior chemotherapy (excluding mobilization therapy)

Patients must have undergone an adequate collection of peripheral blood stem cells (PBSC) according to accepted procedures at each individual institution

Patients must be negative for antibody to HIV and this test must have been performed within 42 days prior to registration; patients must not have an autoimmune disease or have had a prior allogeneic (from someone else) organ or tissue transplant

If day 28 or 42 falls on a weekend or holiday, the limit may be extended to the next working day; in calculating days of tests and measurements, the day a test or measurement is done is considered day 0; therefore, if a test is done on a Monday, the Monday four weeks later would be considered day 28; this allows for efficient patient scheduling without exceeding the guidelines

No prior malignancy is allowed except for adequately treated basal cell (or squamous cell) skin cancer, in situ cervical cancer or other cancer for which the patient has been disease-free for five years

Pregnant or nursing women may not participate; women or men of reproductive potential may not participate unless they have agreed to use an effective contraceptive method

Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines

At the time of patient registration, the treating institution's name and ID number must be provided to the statistical center in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered into the database

REGISTRATION # 2 (RANDOMIZATION)

Patients who are less than 28 days or more than 80 days after PBSCT will not be registered for randomization

Patients known to be ineligible for registration step #1 may not be registered to registration step #2

ANC \> 500 mm\^3

Platelet count supportable to \> 20,000/mm\^3 with no more than one transfusion per day

The patient must be free of active bacterial, fungal or viral infection, afebrile, off antibiotics, antifungal and antiviral agents (with the exception of prophylactic therapy) for three consecutive days

Bilirubin =\< 2 times the institutional upper limit of normal; test must be completed within 7 days prior to registration

SGOT or SGPT =\< 2 times the institutional upper limit of normal; test must be completed within 7 days prior to registration

Alkaline phosphatase =\< 2 times the institutional upper limit of normal; test must be completed within 7 days prior to registration

Creatinine =\< 1.5 times the institutional upper limit of normal; test must be completed within 7 days prior to registration

The patient must have =\< grade 1 cardiac, pulmonary, CNS, renal, hepatic, GI toxicity and \< grade 3 mucosal toxicity according to the Southwest Oncology Group Toxicity Criteria

The patient must have received no amphotericin B, corticosteroids, pentoxifylline, or growth factors for at least 72 hours prior to registration

The patient must have a current Southwest Oncology Group performance status of 0-2

Patients must have an EKG with no active cardiac disease and a chest x-ray with no active pulmonary disease; these tests must be completed within 7 days prior to registration

Patients must not have an autoimmune disease or have had a prior allogeneic (from someone else) organ or tissue transplant

What this study is about