A Study of 141W94 in Combination With Other Anti-HIV Drugs

Inclusion Criteria

• •Concurrent Medication:
• •Allowed provided used with caution:
• •Medications that may interact at CYP3A4 (either a substrate, inhibitor or inducer of the enzyme) should be used with caution.
• •Patients must have:
• •Documented HIV infection.
• •CD4+ cell count \>= 200 cells/mm3.
• •1\. Anticipated need for treatment with cytotoxic chemotherapeutic agents within the study time period.
• •Treatment with immunomodulating agents.
• •Medications that should not be administered with 141W94:
• •Terfenadine. Astemizole. Cisapride. Triazolam. Midazolam. Ergotamine/Dihydroergotamine-containing regimens. Antiretroviral drugs. Vitamin E supplements. Other experimental agents.
• •Anticipated need for radiation therapy within the study time period.
• •1\. Prior protease inhibitors.
• •Antiretroviral therapy within 2 weeks prior to entry.
• •Treatment with cytotoxic chemotherapeutic agents within 4 weeks prior to entry.
• •Radiation therapy within 4 weeks prior to entry. Current alcohol or illicit drug use that, in the opinion of the investigator, may interfere with the patient's ability to comply with the dosing and protocol evaluations.