The Safety and Effectiveness of Clarithromycin Plus Ethambutol Used With or Without Clofazimine in the Treatment of MAC in Patients With AIDS

Exclusion Criteria

• •Concurrent Medication:
• •Excluded:
• •Active therapy with carbamazepine or theophylline, unless investigator agrees to carefully monitor blood levels.
• •Active therapy with investigational drugs other than treatment for HIV disease, except with approval of the sponsor.
• •Concomitant terfenadine (Seldane or Seldane-D) or astemizole (Hismanal).
• •Amikacin.
• •Azithromycin.
• •Capreomycin.
• •Ciprofloxacin.
• •Cycloserine.
• •Ethionamide.
• •Gentamicin.
• •Kanamycin.
• •Levofloxacin.
• •Lomefloxacin.
• •Ofloxacin.
• •Rifampin.
• •Rifabutin.
• •Sparfloxacin.
• •Streptomycin.
• •Any other aminoglycosides, quinolones, and macrolides.
• •Patients with the following prior conditions are excluded:
• •History of allergy or hypersensitivity to macrolides, ethambutol, or clofazimine.
• •Prior Medication:
• •Excluded:
• •Other antimycobacterials, including aminoglycosides, ansamycin (rifabutin), other macrolides (such as clindamycin), quinolones, and rifampin, between screening and study entry.
• •Clarithromycin or azithromycin as prophylaxis or treatment (for any cause) for more than 14 days cumulative within the past 2 months.