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A Comparison of Fluconazole and Ketoconazole in the Treatment of Fungal Infections of the Throat in Patients With Weakened Immune Systems | Clinical Trials | Clareo Health

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A Comparison of Fluconazole and Ketoconazole in the Treatment of Fungal Infections of the Throat in Patients With Weakened Immune Systems

A Randomized Comparative Multicenter Trial of Fluconazole and Ketoconazole in the Treatment of Esophageal Candidiasis in Immunocompromised Patients

NCT00002304•Pfizer

View on ClinicalTrials.gov

Summary

To compare the safety, tolerance, and effectiveness of fluconazole and ketoconazole in the treatment of candidal esophagitis in immunocompromised patients.

Eligibility

Age

13 - 70 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Prior Medication:
•Allowed:
•Cyclosporin if levels can be monitored for proper cyclosporin dose adjustment.

Exclusion Criteria

•Co-existing Condition:
•Patients with the following are excluded:
•Evidence of noncandidal systemic fungal infections.
•Leukopenia (white blood cell count less than 1000/mm3), or expected to develop leukopenia during the study.
•Other condition known to be associated with poor ketoconazole absorption, e.g., hypochlorhydria.
•Leukemia requiring chemotherapy.
•Any other condition which in the opinion of the investigator would make the patient unsuitable for enrollment.
•Concurrent Medication:
•Excluded:
•Warfarin.
+18 more criteria

Locations (42)

Good Samaritan Med Ctr

Phoenix, Arizona, United States

Arkansas Children's Hosp

Little Rock, Arkansas, United States

Los Angeles County - USC Med Ctr

Los Angeles, California, United States

Eisenhower Med Ctr

Rancho Mirage, California, United States

ViRx Inc

San Francisco, California, United States

UCSF Hosp

San Francisco, California, United States

George Washington Univ Med Ctr

Washington D.C., District of Columbia, United States

Regional Oncology Ctr

Daytona Beach, Florida, United States

Ctr for Special Immunology

Fort Lauderdale, Florida, United States

Mem Hosp Hollywood

Hollywood, Florida, United States

Key Dates

Last Updated

June 24, 2005

Conditions

Candidiasis, EsophagealHIV Infections

Interventions

Ketoconazole

DRUG

Fluconazole

DRUG

Skeletal Muscle Energetics and Fatiguability in Older Individuals

NCT04142047

HIVHIV Infections

View study

RECRUITINGPHASE3

A Study to Evaluate the Effectiveness of Long-acting (LA) Cabotegravir (CAB) + Rilpivirine (RPV) LA When Given to Participants With Detectable HIV-1

NCT06694805

HIV Infections

View study

RECRUITING

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 24, 2005Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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A Comparison of Fluconazole and Ketoconazole in the Treatment of Fungal Infections of the Throat in Patients With Weakened Immune Systems

Inclusion Criteria

Exclusion Criteria

Skeletal Muscle Energetics and Fatiguability in Older Individuals

A Study to Evaluate the Effectiveness of Long-acting (LA) Cabotegravir (CAB) + Rilpivirine (RPV) LA When Given to Participants With Detectable HIV-1

Clinic vs Clinic+Community Outreach HPV Self-Collection to Increase Cervical Screening in Women With HIV

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