A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients With AIDS
Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Pfizer
Age
13–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Concurrent Medication:
Allowed:
Cimetidine.
You may not be if
Co-existing Condition:
Patients with the following are excluded:
Known history of intolerance or allergy to imidazoles or triazoles, or the non-azole components of clotrimazole troches (dextrose, cellulose, povidone, magnesium stearate).
Moderate or severe liver disease defined by specified lab values.
Concurrent Medication:
Excluded pending results of phase I studies to determine whether interaction between fluconazole and these agents occurs:
Barbiturates.
Phenytoin.
Coumarin-type anticoagulants.
Rifampin.
Oral hypoglycemics.
Cyclosporin.
Patients with the following are excluded:
Known history of intolerance or allergy to imidazoles or triazoles, or the non-azole components of clotrimazole troches (dextrose, cellulose, povidone, magnesium stearate).
Unable to tolerate oral medication.
Moderate or severe liver disease defined by specified lab values.
Life expectancy \< 4 weeks.
Unable or unwilling to be followed at the same center for the conduct of this study.
Prior Medication:
Excluded within 3 days of study entry:
Other antifungal agents.
Excluded pending results of phase I studies to determine whether interaction between fluconazole and these agents occurs:
Barbiturates.
Phenytoin.
Coumarin-type anticoagulants.
Rifampin.
Oral hypoglycemics.
Cyclosporin.
Patients meeting CDC criteria for diagnosis of AIDS, or having serologic or virologic evidence of HIV infection (but without AIDS-defining opportunistic infections as of yet).
Patients who have given informed consent in writing to their participation in the study.
Patients with signs of oropharyngeal candidiasis, i.e., with typical white plaques.
Clareo Health | A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients With AIDS
