Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Pharmacia and Upjohn
Age
18–45
Sex
MALE
Healthy volunteers
Not accepted
You may be eligible if
Patients must have:
Enrollment on protocol RV-43 (AZT resistance study).
Development of a primary RV-43 study endpoint-opportunistic infection.
HIV isolate with an AZT IC50 \> 50 times that of the sensitive type strain.
Able to swallow tablets without difficulty.
Normal QTc interval on EKG.
You may not be if
Co-existing Condition:
Patients with the following symptoms or conditions are excluded:
Clinically significant hypersensitivity to piperazine type drugs (Antepar, Stelazine).
Severe uncontrollable diarrhea or vomiting or known malabsorption.
Symptomatic hyperlipidemia.
Concurrent Medication:
Excluded:
Other experimental drugs.
AZT, ddI, ddC, foscarnet, immunomodulators or other agents with primary antiretroviral activity (exemptions by principal investigator permitted).
Patients with the following prior conditions are excluded:
History of clinically significant cardiovascular disease or nervous system or muscle disease, including seizures, peripheral neuropathy, dementia, or motor dysfunction.
Prior Medication:
Excluded:
Experimental drugs within 4 weeks prior to study entry.
