Local Flurbiprofen to Treat Pain Following Wisdom Tooth Extraction

Inclusion Criteria

• •Patients of either sex requiring removal of two impacted mandibular third molars (partial bony or soft tissue impaction).
• •16 years of age of older.
• •Indicates willingness to undergo oral surgery with local anesthesia and intravenous midazolam only.
• •Willing to return for the removal of the remaining maxillary third molars at a second appointment.
• •Patients with a history of allergy to flurbiprofen, aspirin, or any NSAID will be excluded.
• •Those with a history of aspirin or NSAID-induced asthma will be excluded.
• •Females of childbearing potential who are not practicing adequate contraception will be excluded.
• •Pregnant or nursing females will be excluded.
• •Patients with recent history or present signs of renal, hepatic, endocrine, pulmonary, cardiac, gastrointestinal, neurologic, or cerebral function impairment will be excluded.
• •Those with psychiatric disorders will be excluded.
• •Patients who have taken an investigational drug within 30 days of this study will be excluded.
• •Those who have taken another analgesic, steroid, opioid, or NSAID within 24 hours prior to the study will be excluded.
• •Those with an absence of bilateral local anesthesia during surgery as evidenced by anesthesia or paresthesia of the lower lip postoperatively will be excluded.
• •Patients who use drugs which will interact with NSAID such as aspirin, warfarin, probenecid, methotrexate, lithium and diuretics will be excluded.