Genetic Study of Schizophrenia

Inclusion Criteria

• •Probands must have a DSM IV-R diagnosis of schizophrenia,schizoaffective disorder, psychosis N.O.S. or schizophreniform disorder.
• •Probands and Siblings must be between the ages of 18 and 55
• •Probands and Siblings must be free of major medical illnesses, but may have controlled hypertension, thyroid disease, or diabetes.
• •Probands and Siblings must have the cognitive ability to consent for themselves. Those who are judged to have the cognitive ability to consent for themselves at the time of participation, but do not have the legal capacity to consent for themselves may participate if the legal guardian /Legal authorized representative (LAR) provides consent by signing the informed consent form.
• •Fluency in English is required.
• •To be eligible for this research study, healthy volunteers must be:
• •Between the ages of 18 and 55
• •Fluency in English is required
• •They have history of DSM IV-R psychiatric diagnosis or severe chronic medical illness at the time of the study.
• •They have a history of any (excepting nicotine-related) DSM5-defined moderate to severe substance use disorder (or DSM-IV-defined substance dependence).
• •They have a cumulative lifetime history of any (excepting nicotine-related) DSM5-defined mild substance use disorder (or any DSM-IV-defined substance abuse), either in excess of 5 years total or not in remission for at least 6 months.
• •They may not be eligible for the 2-day or 1-day study if they have a first-degree relative with history of schizophrenia spectrum disorders. However, they may be included in the SCID\_DNA or case control analyses.
• •Healthy volunteers must be free of learning disabilities.
• •NIMH employees/staff and their immediate family members will be excluded from the study per NIMH policy.