Effects of Drugs on Cerebral Blood Flow in Patients With Mood Disorders

Inclusion Criteria

• •Healthy volunteers and patients who satisfy DSM-III-R criteria for mood disorders between ages of 18 and 75 will be invited to participate provided that the following criteria are fulfilled:
• •No history of medical illness (including seizures, endocrine, hepatic, renal, cardiac, allergic, infectious, autoimmune, or neurological disorders) that would contraindicate participation.
• •No evidence of co-existing major illness after undergoing complete psychiatric (including SADS-LA interview), medical, neurological, and laboratory examinations (including EEG, EKG, renal and liver function tests, serum electrolytes, urinalysis, HIV, hepatitis B, syphilis).
• •Negative pregnancy test for women of child bearing potential.
• •Women must not be breast feeding.
• •Negative HIV test, as we are studying primary mood and anxiety disorders and not disorders secondary to HIV infection.
• •Negative urine comprehensive drug screen and have not had alcohol or substance abuse problems in last 12 months.