The Effects of Reproductive Hormones on Mood and Behavior

Exclusion Criteria

• •The following conditions will constitute contraindications to treatment with hormonal therapy and will preclude a subject's participation in this protocol:
• •Current Axis I psychiatric diagnosis (with the exception of this women with a past major depression who will be studied on this protocol);
• •History consistent with endometriosis;
• •Diagnosis of ill-defined, obscure pelvic lesions, particularly undiagnosed ovarian enlargement;
• •Hepatic disease as manifested by abnormal liver function tests;
• •History of mammary carcinoma;
• •History of pulmonary embolism or phlebothrombosis;
• •Undiagnosed vaginal bleeding;
• •Porphyria;
• •Diabetes mellitus;
• •History of malignant melanoma;
• •Cholecystitis or pancreatitis;
• •Cardiovascular or renal disease;
• •Pregnancy;
• •Any woman meeting the Stages of Reproductive Aging Workshop Criteria (STRAW) for the perimenopause (129). Specifically, we will exclude any woman with an elevated plasma follicle stimulating hormone (FSH) level (greater than or equal to 14 IU/L) and with menstrual cycle variability of \> 7 days different from their normal cycle length.
• •National Institute of Mental Health (NIMH) employees/staff and their immediate family members will be excluded from the study per NIMH policy.
• •Subjects taking birth control pills will be excluded from the study.
• •Subjects taking diuretics, prostaglandin inhibitors, or pyridoxine (putative treatments for MRMD) will similarly be excluded from the study, as will patients taking psychotropic agents (e.g., lithium carbonate, tricyclic antidepressants).
• •All subjects will be required to use non-hormonal forms of birth control (e.g., barrier methods) to avoid pregnancy during this study.
• •Participants who have an active condition that places them at an increased risk for osteoporosis will be excluded from this protocol.