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RECRUITINGNCT00001276

Diagnosing and Treating Low Blood Sugar Levels

Hypoglycemia is the term used to refer to lower than normal levels of blood sugar. This study will continue to research the causes of hypoglycemia. Patients involved in the study will be admitted to ...

Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)•1 U.S. locations•View source on ClinicalTrials.gov

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Contacts

Craig S Cochran, R.N.

CONTACT

(301) 402-1880 craigc@bdg10.niddk.nih.gov

Ranganath Muniyappa, M.D.

CONTACT

(301) 451-7702 muniyapr@mail.nih.gov

Sponsors

Lead Sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Study Description: The purpose of this study is to gain knowledge and experience in the diagnosis and therapy of patients with fasting hypoglycemia due to diverse etiologies, such as insulinomas. Study subjects will be evaluated and treated for their particular condition according to standard care. Objectives: 1. To understand the pathophysiology and various causes of hypoglycemia (e.g., insulinomas, MEN1, MEN2). 2. To identify new circulating biomarkers of insulinomas. 3. To create a repository of clinical data and samples for future research of insulinomas. Endpoints: None

Age

18 - 120 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•In order to be eligible to participate in this study, an individual must meet all of the following criteria:
•1. Male, females ages \>= 18.
•2. Patients with documented fasting blood glucose below 55 mg/dl.
•4\. Patients with biochemical evidence for insulinoma or other pancreatic neuroendocrine tumors.

Exclusion Criteria

•An individual who meets any of the following criteria will be excluded from participation in this study:
•1. Patients with significant cardiac disease will be excluded.
•2. Subjects who are pregnant per self-report.
•3. Medically unstable per the assessment of the PI.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: February 20, 2026Terms

Trial snapshot

StatusRECRUITING

Phase—

Enrollment1,500

Start dateMay 1991

Last updatedFeb 20, 2026

Condition

Hypoglycemia Insulinoma

Locations shown

National Institutes of Health Clinical Center

Bethesda, Maryland

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 20, 2026Data synced to Clareo: May 10, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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