Heart Disease Clinical Trials in North Carolina

Showing 201-220 of 514 trials

Genomic Outcomes of Metformin

NCT02986659

Medical scientists have found that people with diabetes who take the drug Metformin have less age-related disease than those taking other treatments and researchers believe it may prevent numerous diseases and conditions that effect older people. In addition, metformin extends lifespan in some animal models of human disease. The purpose of this study is to see if taking Metformin causes changes in blood cells consistent with improved health and longevity in people who do not have diabetes. In this study Metformin will be compared to placebo. A placebo is a substance, like a sugar pill, that is not thought to have any effect on a participants disease or condition. In this study participants will either receive the active study medication, Metformin or placebo which is not active. Placebos are used in research studies to see if the drug being studied really does have an effect.

Coronary Artery DiseaseMild Cognitive ImpairmentObesity, Abdominal+1 more

Wake Forest University Health Sciences30 participantsStarted Aug 2016

Winston-Salem, North Carolina, United States

UNKNOWNNA41 miles

Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The ECLIPSE Trial

NCT03108456

This trial will evaluate Orbital Atherectomy compared to conventional balloon angioplasty technique for the treatment of severely calcified lesions prior to implantation of drug-eluting stents (DES).

Coronary Artery DiseaseIschemic Heart DiseaseNon ST Segment Elevation Myocardial Infarction

Abbott Medical Devices2,005 participantsStarted Mar 2017

Birmingham, Alabama, United States • Chandler, Arizona, United States • Phoenix, Arizona, United States +101 more locations

Genomic Outcomes of Metformin

Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The ECLIPSE Trial

Heart Disease Trials in Other Cities

Study to Assess the Safety and Tolerability of IV Tonapofylline in Subjects With Acute Decompensated Heart Failure (ADHF) and Renal Insufficiency

Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care

Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Preserved Ejection Fraction

Family Health History in Diverse Care Settings (FHH)

Hybrid Effectiveness-Implementation Study to Improve Clopidogrel Adherence

Left Atrial Pressure Monitoring to Optimize Heart Failure Therapy

Multi-center Prospective Study to Evaluate Outcomes of the Moderate to Severely Calcified Coronary Lesions (MACE)

A Clinical Trial to Confirm Safety & Effectiveness of the SYNERGY 4.50 mm and 5.00 mm Stent for Treatment of Atherosclerotic Lesion(s)

Randomized Evaluation of Patients With Stable Angina Comparing Diagnostic Examinations

Study of Heart Failure Hospitalizations After Aquapheresis Therapy Compared to Intravenous (IV) Diuretic Treatment

Congenital Heart Disease: Impact on Learning and Development in Down Syndrome (CHILD-DS)

Evaluate the Safety and Efficacy of OAS in Treating Severely Calcified Coronary Lesions

A Clinical Evaluation of the MINI TREK RX 1.20 mm Coronary Dilatation Catheter in Stenotic Lesions

Identifying and Facilitating Ventricular Recovery on Mechanical Support

C-Pulse IDE Feasibility Study- A Heart Assist System

ANTHEM-HFrEF Pivotal Study

Resynchronization/Defibrillation for Ambulatory Heart Failure Trial

Association of Endothelial Function and Clinical Outcomes in Subjects Admitted to Chest Pain Unit

Other Conditions in North Carolina