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Comparing Iron Absorption From Multiple Micronutrient Supplements and Iron-folate Supplements: a Stable Isotope Study in Kenyan Pregnant Women
This study evaluates iron absorption from three antenatal supplements, 30 mg MMS, 60 mg MMS, and 60 mg IFA, in 50 pregnant Kenyan women in their second trimester. Using a randomized crossover design and stable iron isotopes, we will compare bioavailability in both fasted and fed states. Additionally, the trial will investigate if daily dosing triggers a hepcidin response that inhibits subsequent absorption, testing whether alternate-day dosing is a more effective strategy for treating iron deficiency.
Age
18 - 35 years
Sex
FEMALE
Healthy Volunteers
No
Kwale Sub County Hospital
Kwale, Kwale County, Kenya
Msambweni County Referral Hospital
Msambweni, Kwale County, Kenya
Start Date
March 2, 2026
Primary Completion Date
July 31, 2026
Completion Date
December 31, 2026
Last Updated
February 27, 2026
50
ESTIMATED participants
MMS with 30 mg iron
DIETARY_SUPPLEMENT
MMS with 60 mg iron
DIETARY_SUPPLEMENT
IFA with 60 mg iron
DIETARY_SUPPLEMENT
Lead Sponsor
ETH Zurich
NCT06768060
NCT07462065
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
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View ClinicalTrials.gov Terms and ConditionsNCT06273683