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Effect of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Severe Depression | Clinical Trials | Clareo Health

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Effect of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Severe Depression

Effect of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Severe Depression: A Randomized Controlled Trial

NCT07374211•Chinese PLA General Hospital

View on ClinicalTrials.gov

Summary

This project employs a prospective, randomized, controlled, blinded, dual-center study design to investigate the effects of intraoperative esketamine on perioperative anxiety and depression symptoms in patients with severe depression undergoing breast cancer surgery.

Eligibility

Age

18 - No limit years

Sex

FEMALE

Healthy Volunteers

Inclusion Criteria

•1. Age ≥ 18 years.
•2. Scheduled to undergo elective breast cancer resection surgery.
•3. American Society of Anesthesiologists (ASA) physical status classification of I-III.
•4. Clearly understand and voluntarily agree to participate in the study, and sign the informed consent form.
•5. Female patients with severe depressive symptoms (defined as a Hospital Anxiety and Depression Scale-Depression subscale score of ≥15)
•6. Anticipated anesthesia duration greater than 90 minutes.

Exclusion Criteria

•1. Patients with significant preoperative abnormalities in cardiac, pulmonary, hepatic, or renal function, or coagulation disorders .
•2. Patients taking antipsychotics, antidepressants, or glucocorticoids, or with a history of alcohol abuse or illicit drug use .
•3. Patients with an MMSE score \<18, dementia, intellectual disability, or those unable to communicate (e.g., coma, severe dementia, hearing or language impairment) .
•4. Patients with a history of psychiatric or neurological disorders (e.g., schizophrenia, epilepsy, Parkinson's disease, or severe myasthenia gravis) .
•5. Patients with poorly controlled or untreated hypertension (≥180/110 mmHg) .
•6. Patients with elevated intracranial or intraocular pressure.
•7. Patients with untreated or inadequately treated hyperthyroidism .
•8. Patients with a known allergy to the drugs involved in this study .
•9. Patients unable to complete the assessment scales required by this study.
•10. Patients who are currently participating in other clinical trials

Key Dates

Start Date

January 18, 2026

Primary Completion Date

January 18, 2026

Completion Date

February 1, 2027

Last Updated

January 28, 2026

Enrollment

242

ESTIMATED participants

Conditions

DepressionAnxietyS-ketamineBreast Cancer

Interventions

Esketamine 0.3mg/kg

DRUG

normal saline

DRUG

Contacts

WEIDONG MI

CONTACT

133810829 wwdd1962@163.com

Weidong Mi Mi

CONTACT

13381082966 wwdd1962@163.com

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 28, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Effect of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Severe Depression

Inclusion Criteria

Exclusion Criteria

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